专用集成电路与系统国家重点实验室
讲座信息
The Development of Neural Prosthetic SoC for Closed-Loop Epileptic Seizure Control
and its Preliminary Chronic Tests on Rats
时 间：4月29日（周三）下午13：30，
地 点：张江校区微电子楼389报告厅
报告人：Herming Chiueh，Associate Professor, Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan.
Abstract:
In recent years, alternative treatments and devices are proposed to investigate and treat epilepsy in addition to pharmacological and surgical treatments. Several prosthesis devices with deep brain stimulation (DBS) or vagus nerve stimulation are becoming popular treatments for epilepsy clients. These devices use open-loop continuous neural stimulations to control medical refractory epilepsies complementarily with the limited effective rate around 45%. Besides, by using continuous stimulations and an implantable battery, lifetime of such a device is often limited and periodically operations for clients are required to replace the battery/devices. To overcome the above limitations, a neural-prosthetic system-on-chip (SoC) for real-time closed-loop epileptic seizure control is proposed for the implantable prosthesis. The designed SoC detects the seizure pattern on iEEG and provides conditional therapeutic stimulation. Preliminarily experimental tests were done in two epileptic animal models using Long-Evans rats, indicating at least 92% seizure detection rate and suppression of seizure activity by conditional therapeutic stimulation. Chronic tests using the portable device with integrated chips and electrodes are currently on going. The proposed prosthetic device with closed-loop epileptic seizure detection and stimulation yields a promising treatment for epileptic seizures.
Biography
Herming Chiueh received his B.S. degree in Electrophysics from National Chiao Tung University, Hsinchu, Taiwan, and the M.S. and Ph.D. degrees in Electrical Engineering from University of Southern California, Los Angeles, CA, USA. From 1996 to 2002, he was with Information Sciences Institute, University of Southern California, Marina del Rey, CA, USA. He has participated in the VLSI effort on several large projects in USC/ISI, which includes the development of a 55-million transistor processing-in-memory (PIM) chip. From 2009 to 2015, he has given more than 30 invited talks regarding his recent research in “closed-loop epileptic seizure detection” and “low-power sigma-delta data converters” in conferences and workshops as well as difference campuses and research institutes. He was the co-recipient of ISSCC 2013 Distinguished-Technical-Paper Award and ISSCC 2013 Demonstration Session Certificate of Recognition to recognize his research in “closed-loop neural-prosthetic SoC.” He currently serves as an Associate Professor in the Department of Electrical and Computer Engineering, National Chiao Tung University, Hsinchu, Taiwan. His research interests include system-on-chip design methodology, low-power integrated circuits, neural interface circuits, and biomimetic systems.
Dr. Chiueh served as Demonstrations Chair on 2012 IEEE Biomedical Circuits and Systems Conferences (BIOCAS 2012,) Conference Secretariat on 2007 IEEE SOC Conference, and Finance Chair on 2007 IEEE International Workshop on Memory Technology, Design and Testing. He is member of Technical Committee on “Biomedical and Life Science Circuits and Systems” and “Nanoelectronics and Gigascale” in IEEE Circuits and Systems Society. He also served as Education Affairs Officer in IEEE Circuits and Systems Society, Taipei Chapter in 2011. He was member of technical program committee and session chair in several conferences, such as ISCAS, MWSCAS, THERMINIC, APSCAS, THETA, and ICECS.
